The modern rhythm of life requires a person to be completely involved in its whirlpool, which is why so many people desperately lack rest. How to overcome the resulting drowsiness? A cup of aromatic coffee often helps to disperse drowsiness and get into active mode. But this method does not always work. Therefore, many people choose an alternative - a drug called “Caffeine”. The instructions for use characterize it as a psychostimulant drug, the effectiveness of which is associated with the alkaloid it contains, produced from tea leaves (2% caffeine), coffee beans (1-2 percent) and cola nuts.

“Caffeine sodium benzoate,” which can be found in pharmacies, is a synthetic drug derived from these compounds.

Pharmacological properties (application)

A methylxanthine derivative, caffeine, has a psychostimulating and analeptic effect on the body. Its main property is the ability to improve motor activity, stimulate positive reflexes and various excitation processes occurring in the cerebral cortex. Thanks to this effect on the body, mental and physical activity increases, drowsiness disappears, and the feeling of fatigue decreases.

Caffeine can also increase blood pressure, but this occurs more often in states of shock or collapse. In small doses, caffeine provides a stimulating effect; in large doses, depression of the nervous system often occurs. What other effects does caffeine have? Instructions for use warn about increased and deepening of breathing when taking the drug, narrowing of blood vessels in the brain and a decrease in oxygen pressure in it. In cases of arterial hypotension, caffeine often normalizes blood pressure. The alkaloid has an antispasmodic effect on smooth muscles and a stimulating effect on striated muscles. Under the influence of caffeine, the secretory activity of the stomach increases and the basal metabolism increases (increased glycogenolysis, accelerated lipolysis). A moderate diuretic effect is also a consequence of caffeine consumption.

"Caffeine": indications for use

The drug is prescribed for diseases accompanied by a depressed state of the central nervous system, for disorders of the cardiovascular and respiratory systems (including poisoning with drugs, alcohol and toxins as a result of an infectious process), asphyxia, asthenia, enuresis (including in children), migraine, to relieve spasms of cerebral vessels. In ophthalmology, caffeine is used after eye surgery to reduce tone and retinal detachment.

This medicine is also indicated for decreased mental and physical performance, drowsiness, and to restore the optimal level of activity. A steady trend in recent years has been the use of this drug as a catalyst for the process of losing weight. In this case, the obligatory conditions are strict adherence to the dosage, doctor’s recommendations and physical activity. In cosmetology, the mixture of “Caffeine-sodium benzoate” and “Capsicam” has proven itself to be an effective anti-cellulite wrap.

Release form

“Caffeine sodium benzonate” (containing up to 40% caffeine) is available in the form of injection solution, tablets and powder (capsules).

Directions for use and dosage

How to take Caffeine correctly? Tablets, the instructions for use of which advise their use orally no more than 2-3 times a day, are prescribed for adults in a single dose of 100-200 mg (no more than 0.4 g) and a daily dose of no more than one gram, for children - according to 25-100 mg. Caffeine ampoules (1 ml) are intended for subcutaneous and subconjunctival administration.

Children are injected subcutaneously with a ten percent caffeine solution of 0.25-1 ml. In ophthalmology, a 10% solution of caffeine in ampoules is also used: no more than 0.3 ml of the drug is dripped under the conjunctiva once a day. The dosage and duration of treatment are prescribed by the doctor and depend on the patient’s condition, as well as the nature of the disease. Caffeine sodium benzoate should not be taken before bed.

Contraindications

The instructions for use do not recommend prescribing the psychostimulant “Caffeine Benzoate” to people with arterial hypertension, increased excitability, sleep disorders (insomnia), those suffering from atherosclerosis, tachycardia, epilepsy, convulsions, increased intraocular pressure (glaucoma). The drug is also contraindicated for children under 12 years of age and elderly people. Anti-cellulite masks should not be applied to affected areas of the skin.

Side effects

When taking a drug containing caffeine, the instructions for use advise paying attention to possible negative reactions of the body: from the central nervous system - anxiety, agitation, tremor, headache, restlessness, convulsions, dizziness, increased muscle tone, increased reflexes, insomnia, tachypnea . If the drug is abruptly discontinued, lethargy, drowsiness, fatigue, and increased inhibition of the central nervous system reaction may occur.

From the cardiovascular system, arrhythmia, tachycardia, and increased blood pressure are possible. From the gastrointestinal tract - nausea, exacerbation of peptic ulcers, vomiting, colic. With long-term use, addiction and dependence on the drug is possible due to the formation of new adenosine receptors in the brain cells.

Overdose

What symptoms can excess caffeine cause? Instructions for use warn in such cases about increased severity of side effects: anxiety, confusion, mental and motor agitation, tremors or muscle twitching, epileptic seizures; dehydration, tachycardia, arrhythmia, headache, ringing in the ears, hyperthermia, frequent urination, nausea and vomiting.

The same conditions can occur after taking 300-600 mg (4 cups) of coffee per day, especially if combined with taking Caffeine Sodium Benzoate tablets.

special instructions

During pregnancy and while breastfeeding, caffeine is taken only in cases of extreme necessity and under the supervision of a doctor! Abuse of the drug and drink threatens possible spontaneous abortion, slowing of intrauterine development, inhibition or disturbances in skeletal development, and arrhythmia in the fetus. During the lactation period, caffeine penetrates into breast milk and, accumulating, threatens insomnia in the baby and its hyperactivity.

"Caffeine": instructions for use, price, storage conditions and expiration date

The drug must be stored away from children, out of reach of them, at temperatures up to 25 degrees, for no more than 5 years.

The cost of “Caffeine-sodium benzoate” tablets (6 pieces) in pharmacies today is approximately 32-40 rubles, a package of 10 ampoules (1 ml) of 20% solution is sold for 40-64 rubles.

Analogs

In addition to tablets produced in blisters of 6 or 10 pieces, as well as a solution for injection in ampoules, in pharmacies you can find drugs with various combinations of substances, which include caffeine. What other medications containing caffeine are listed in the instructions for use of medications? Expert reviews call the following analogues: “Askofen” (40 mg) and “Coficil Plus” (50 mg of the substance in question), “Migrenol” and “Solpadeine Fast” - 65 mg each, “Aquacitramon” (45 mg), as well as “Citramon” "and regular "Solpadeine" - 30 mg each. Among the drinks containing this common psychostimulant, reviews on forums mention coffee, tea, hot chocolate and soda (cola). The weight loss product Liquid Chestnut, which contains guaranine (an analogue of caffeine and theine), has a double concentration of caffeine.

Use is only possible after consultation with a doctor if the expected benefit to the mother outweighs the potential risk to the fetus.

Side effect

From the side of the central nervous system: sleep disturbance, agitation, anxiety; With prolonged use, addiction is possible.

From the cardiovascular system: tachycardia, increased blood pressure, arrhythmias.

From the digestive system: nausea, vomiting.

Release form

Tablets 1 tab.
caffeine sodium benzoate 100 mg
10 pieces. - contour cell packaging (1) - cardboard packs.

Interaction with other drugs

When used simultaneously, the effect of sleeping pills and anesthetics is reduced.

With simultaneous use, it is possible to enhance the effect of analgesics-antipyretics, salicylamide, naproxen.

With the simultaneous use of estrogens (hormonal contraceptives, drugs for HRT), it is possible to increase the intensity and duration of action of caffeine due to inhibition of the CYP1A2 isoenzyme by estrogens.

When administered concomitantly with adenosine, caffeine reduces the increased heart rate and blood pressure changes caused by adenosine infusion; reduces vasodilation caused by the action of adenosine.

With simultaneous use, it is possible to increase the bioavailability, absorption rate and plasma concentration of acetylsalicylic acid.

With simultaneous use, mexiletine reduces the clearance of caffeine and increases its plasma concentrations, apparently due to mexiletine inhibition of caffeine metabolism in the liver.

Methoxsalen reduces the excretion of caffeine from the body with a possible increase in its effect and the development of toxic effects.

Due to the induction of microsomal liver enzymes under the influence of phenytoin, its simultaneous use accelerates the metabolism and excretion of caffeine.

Fluconazole and terbinafine cause a moderate increase in the concentration of caffeine in the blood plasma, ketoconazole - less pronounced.

The most pronounced increase in AUC and decrease in clearance are observed with simultaneous use of caffeine with enoxacin, ciprofloxacin, pipemidic acid; less pronounced changes - with pefloxacin, norfloxacin, fleroxacin.

When used simultaneously, caffeine accelerates the absorption of ergotamine.

Compound

Caffeine sodium benzoate 100 mg

Storage conditions

In a dry place, protected from light, at a temperature not exceeding 25 0 C.

Keep out of the reach of children.

Overdose

Symptoms: gastralgia, agitation, anxiety, agitation, motor restlessness, confusion, delirium, dehydration, tachycardia, arrhythmia, hyperthermia, frequent urination, headache, increased tactile or pain sensitivity, tremor or muscle twitching; nausea and vomiting, sometimes with blood; ringing in the ears, convulsions (in case of acute overdose - tonic-clonic).

Caffeine in doses of more than 300 mg/day (including against the background of coffee abuse - more than 4 cups of natural coffee, 150 ml each) can cause anxiety, tremor, headache, confusion, extrasystole. Treatment: gastric lavage; - if caffeine was taken in the last 4 hours at a dose of more than 15 mg/kg and there was no vomiting caused by caffeine; taking activated carbon, laxatives; for hemorrhagic gastritis - administration of antacid medications and gastric lavage with ice-cold 0.9% sodium chloride solution; maintaining pulmonary ventilation and oxygenation; for convulsions - intravenous diazepam, phenobarbital or phenytoin; maintaining water and electrolyte balance.

special instructions

It can be used as mono or as part of combination therapy.

Contraindications

Arterial hypertension, organic diseases of the cardiovascular system (including severe atherosclerosis), glaucoma, increased excitability, sleep disorders, old age.

With caution (Precautions)

Glaucoma, increased excitability, old age, epilepsy and a tendency to seizures.

Best before date

Product description

Pills

pharmachologic effect

Psychostimulant and analeptic drug, a derivative of methylxanthine. Competitively blocks central and peripheral A1 and A2 adenosine receptors. Inhibits the activity of PDE in the central nervous system, heart, smooth muscle organs, skeletal muscles, adipose tissue, promotes the accumulation of cAMP and cGMP in them (this effect is observed when used only in high doses). Stimulates the centers of the medulla oblongata (respiratory and vasomotor), as well as the n.vagus center, has a direct stimulating effect on the cerebral cortex. In high doses, it facilitates interneuronal conduction in the spinal cord, enhancing spinal reflexes.

Increases mental and physical performance, stimulates mental activity, motor activity, shortens reaction time, temporarily reduces fatigue and drowsiness. In small doses, the stimulating effect predominates, and in large doses, the effect of depression of the nervous system predominates.

Speeds up and deepens breathing. Usually it has a positive ino-, chrono-, bathmo- and dromotropic effect (since the effect on the cardiovascular system consists of a direct stimulating effect on the myocardium and a simultaneous stimulating effect on the n.vagus centers, the resulting effect depends on the predominance of one or another action). Stimulates the vasomotor center and has a direct relaxing effect on the vascular wall, which leads to dilation of the vessels of the heart, skeletal muscles and kidneys, while the tone of the cerebral arteries increases (causes a narrowing of the blood vessels of the brain, which is accompanied by a decrease in cerebral blood flow and oxygen pressure in the brain).

Blood pressure changes under the influence of vascular and cardiac mechanisms of caffeine's influence: with normal initial blood pressure, caffeine does not change or slightly increases it; with arterial hypotension, it normalizes it.

It has an antispasmodic effect on smooth muscles (including a bronchodilator effect), and a stimulating effect on striated muscles.

Increases the secretory activity of the stomach.

It has a moderate diuretic effect, which is due to a decrease in the reabsorption of sodium and water ions in the proximal and distal renal tubules, as well as dilation of renal vessels and increased filtration in the renal glomeruli.

Reduces platelet aggregation and histamine release from mast cells.

Increases basal metabolism: increases glycogenolysis, increases lipolysis.

Pharmacokinetics

When taken orally, absorption is good; occurs throughout the intestine. It is quickly distributed in all organs and tissues of the body, penetrates the blood-brain barrier and the placenta. The maximum concentration in blood plasma is achieved after 50-75 minutes; the half-life is 3.9-5.3 hours (sometimes up to 10 hours). Communication with blood proteins (albumin) - 15%. More than 90% is metabolized in the liver, in children of the first years of life up to 10-15%. Caffeine is metabolized in the liver (the main part is dimethylated and oxidized) with the formation of 5 metabolites. Caffeine and its metabolites are excreted by the kidneys (10% unchanged).

Indications for use

Diseases accompanied by depression of the central nervous system, functions of the cardiovascular and respiratory systems (including poisoning with opioid analgesics, infectious diseases), cerebral vascular spasms, decreased mental and physical performance, drowsiness.

Directions for use and doses

Administered subcutaneously or taken orally. Adults - 100-200 mg 2-3 times/day; children - 25-100 mg 2-3 times/day.

Dosage form

White tablets of flat-cylindrical shape with a chamfer and a score.

Compound

Composition per 1 tablet:

Active substance: caffeine-sodium benzoate-100 mg;

Excipients: potato starch - 15.77 mg, calcium stearate - 0.23 mg;

Pharmacodynamics

Caffeine is a methylxanthine that has a psychostimulant and analeptic effect.

Competitively blocks central and peripheral AT and A2 adenosine receptors. Inhibits the activity of phosphodiesterase in the central nervous system, heart, smooth and striated muscle tissue, adipose tissue, promotes the accumulation of cyclic adenosine monophosphate and cyclic guanosine monophosphate in them (this effect is observed when using only high doses of caffeine). Stimulates the centers of the medulla oblongata (respiratory and vasomotor), as well as the center of the vagus nerve, has a direct stimulating effect on the cerebral cortex. In high doses, it facilitates interneuronal conduction in the spinal cord, enhancing reflexes.

Increases mental and physical performance, stimulates mental activity, motor activity, shortens reaction time, temporarily reduces fatigue and drowsiness. In low doses, the stimulating effect predominates, and in large doses, the effect of depression of the nervous system predominates.

It quickens and deepens breathing, usually has a positive ino-, chrono-, batmo- and dromotropic effect (since the effect on the cardiovascular system consists of a direct stimulating effect on the myocardium and a simultaneous stimulating effect on the center of the vagus nerve, the resulting effect depends on the predominance one action or another).

Stimulates the vasomotor center and has a direct relaxing effect on the vascular wall, which leads to dilation of the blood vessels of the heart, skeletal muscles and kidneys, while the tone of the cerebral arteries increases (causes a narrowing of the brain vessels, which is accompanied by a decrease in cerebral blood flow). Blood pressure changes under the influence of vascular and cardiac mechanisms of caffeine's influence: with normal initial blood pressure, caffeine does not change or slightly increases it, but with arterial hypotension it increases it.

It has an antispasmodic effect on smooth muscles (including a bronchodilator effect), and a stimulating effect on striated muscles. Increases gastric secretory activity and diuresis (decreased reabsorption of sodium and water in the proximal and distal renal tubules, as well as dilation of renal vessels and increased filtration in the renal glomeruli).

Reduces platelet aggregation and histamine release from mast cells. Increases basal metabolism: increases glycogenolysis, increases lipolysis.

Pharmacokinetics

When taken orally, absorption is good; occurs throughout the intestine. It is quickly distributed in all organs and tissues of the body, penetrates the blood-brain barrier and the placenta. The maximum concentration in blood plasma is achieved after 50-75 minutes; the half-life is 3.9-5.3 hours (sometimes up to 10 hours). Communication with blood proteins (albumin) - 15%. More than 90% is metabolized in the liver, in children of the first years of life up to 10-15%. Caffeine is metabolized in the liver (the main part is dimethylated and oxidized) with the formation of 5 metabolites. Caffeine and its metabolites are excreted by the kidneys (10% unchanged).

Side effects

From the central nervous system: psychomotor agitation, anxiety, tremor, restlessness, headache, dizziness, epileptic seizures, increased reflexes, tachypnea, insomnia; with sudden withdrawal - increased inhibition of the central nervous system, increased fatigue, drowsiness, muscle tension. From the cardiovascular system: palpitations, tachycardia, increased blood pressure.

From the digestive system: nausea, vomiting, exacerbation of peptic ulcer.

Other: nasal congestion, with prolonged use - addiction, drug dependence.

Selling Features

prescription

Special conditions

It should be borne in mind that sudden cessation of use may lead to increased inhibition of the central nervous system (drowsiness, depression).

The effect on the central nervous system depends on the type of nervous system and can manifest itself as both excitation and inhibition of higher nervous activity.

Due to the fact that the effect of caffeine on blood pressure consists of vascular and cardiac components, as a result, both the effect of stimulating the heart and inhibition (weak) of its activity can develop.

Do not take before bedtime.

Impact on the ability to drive vehicles. Wed and mechanisms

During the treatment period, care must be taken when driving vehicles and engaging in other potentially hazardous activities that require concentration and speed of psychomotor reactions.

Indications

Decreased mental and physical performance, drowsiness, headache of vascular origin (including migraine), moderate arterial hypotension.

Contraindications

Hypersensitivity to the components of the drug (including other xanthines), anxiety disorders (agoraphobia, panic disorders), organic diseases of the cardiovascular system (including acute myocardial infarction, atherosclerosis), paroxysmal tachycardia, ventricular extrasystole, arterial hypertension, sleep disorders, children under 12 years of age.

Carefully:

Glaucoma, increased excitability, old age, epilepsy and a tendency to seizures.

Pregnancy and lactation:

Use is only possible after consultation with a doctor if the expected benefit to the mother outweighs the potential risk to the fetus.

Drug interactions

Caffeine is an adenosine antagonist (larger doses of adenosine may be required).

With the combined use of caffeine and barbiturates, primidone, anticonvulsants (hydantoin derivatives, especially phenytoin), it is possible to enhance metabolism and increase the clearance of caffeine; cimetidine, oral contraceptives, disulfiram, ciprofloxacin, norfloxacin - decreased metabolism of caffeine in the liver.. (slowing its excretion and increasing its concentration in the blood).

Monoamine oxidase inhibitors, furazolidone, procarbazine and selegiline - large doses of caffeine (more than 300 mg / day) can cause the development of life-threatening cardiac arrhythmias or a marked increase in blood pressure.

Caffeine reduces the absorption of calcium preparations in the gastrointestinal tract.

Reduces the effectiveness of narcotic and sleeping pills.

Increases the excretion of lithium drugs in the urine;

Accelerates absorption and enhances the effect of cardiac glycosides, increasing their toxicity. Concomitant use with beta-blockers may lead to mutual suppression of therapeutic effects; with β-adrenergic agonists - to additional stimulation of the central nervous system and other additive toxic effects.

Caffeine may decrease clearance; theophylline and possibly other xanthines, increasing the potential for additive pharmacodynamic and toxic effects.

Prices for Caffeine-sodium benzoate in other cities

Instructions for use
Caffeine-sodium benzoate solution d/in. 20% 1ml No. 10

Dosage forms
injection solution 20% 1ml

Group
Psychomotor stimulants - purine and imidazole derivatives

International nonproprietary name
Caffeine

Compound
Caffeine.

Manufacturers
Belmedpreparaty (Belarus), Biokhimik OJSC (Russia), Borisov Medical Preparations Plant (Belarus), Dalkhimfarm (Russia), Darnitsa Pharmaceutical Company (Ukraine), Moscow Endocrine Plant (Russia), Moskhimfarmpreparaty im. ON THE. Semashko (Russia), Chelyabinsk Chemical Plant (Russia)

pharmachologic effect
Analeptic, psychostimulant, cardiotonic. It has a stimulating effect on the central nervous system, increases reflex excitability of the spinal cord, stimulates the respiratory and vasomotor centers, regulates and enhances excitation processes in the cerebral cortex. Increases mental and physical performance, reduces fatigue and drowsiness. Increases the strength and frequency of heart contractions (especially in large doses), increases blood pressure during hypotension (does not change normal). Dilates the blood vessels of skeletal muscles, heart, kidneys, bronchi, narrows the abdominal organs. Increases the secretory activity of the stomach. Reduces platelet aggregation. Has a moderate diuretic effect. Blocks central and peripheral adenosine receptors. Stabilizes transmission at dopaminergic synapses, beta-adrenergic synapses of the hypothalamus and medulla oblongata, cholinergic synapses of the cortex and medulla oblongata, noradrenergic synapses. The effect of caffeine largely depends on the type of nervous system in the patient, so dosing of caffeine should take into account the individual characteristics of nervous activity.

Side effect
Anxiety, agitation, insomnia, tachycardia, arrhythmias, increased blood pressure, nausea, vomiting. With long-term use, slight addiction is possible (a decrease in the effect of caffeine is associated with the formation of new adenosine receptors in brain cells). Sudden cessation of caffeine administration may lead to increased central nervous system inhibition with symptoms of fatigue, drowsiness and depression.

Indications for use
Diseases accompanied by depression of the functions of the central nervous system, cardiovascular system, respiratory system (drug poisoning, infectious diseases, etc.). For cerebral vascular spasms, to increase mental and physical performance, to eliminate drowsiness, breathing problems, enuresis in children.

Contraindications
Severe arterial hypertension, organic diseases of the cardiovascular system (including atherosclerosis), increased excitability, glaucoma, sleep disorders, old age.

Directions for use and dosage
Adults: 1 ml of 10% or 20% solution subcutaneously. Higher doses for adults under the skin: single dose 0.4 g, daily dose 1 g. Children: 0.25 - 1 ml of a 10% solution subcutaneously, depending on age. Doses must be selected individually.

Overdose
When abused, caffeine (more than 300 mg per day, i.e. four 150 ml cups of natural coffee) can cause anxiety, restlessness, tremors, headache, confusion, and cardiac extrasystoles. In newborns (including premature infants), at a blood plasma concentration of 50 mg/ml, toxic effects are possible: anxiety, tachypnea, tachycardia, tremor, increased Moro reflex, and at higher concentrations - convulsions.

Interaction
Reduces the effect of sleeping pills and narcotics, increases (improving bioavailability) - acetylsalicylic acid, paracetamol and other non-narcotic analgesics. Improves the absorption of ergotamine in the gastrointestinal tract.

special instructions
No data.

Storage conditions
List B. In a place protected from light, at room temperature.

Trade name of the drug: Caffeine sodium benzoate

International nonproprietary name:

caffeine

Dosage form:

solution for subcutaneous and subconjunctival administration

Compound

1 ml of solution contains 100 mg or 200 mg of sodium caffeine benzoate as an active substance and excipients - sodium hydroxide 0.1 M solution and water for injection.

Description

Transparent colorless or slightly colored liquid.

Pharmacotherapeutic group:

psychostimulant

ATX Code:

Pharmacodynamics

It has a psychostimulating and analeptic effect. It has a stimulating effect on the central nervous system (CNS), increasing excitation in the cerebral cortex, respiratory and vascular-motor centers, activates conditioned reflexes and physical performance, reduces drowsiness and fatigue, causes deepening and rapid breathing, increases heart rate, increases blood pressure pressure during hypotension, dilates the bronchi, bile ducts, blood vessels of skeletal muscles, reduces platelet aggregation, has a moderate diuretic effect, stimulates the secretion of gastric juice, increases basal metabolism and enhances glycogenolysis, causing hyperglycemia. Multiple pharmacological effects of the drug are due to the blockade of central and peripheral adenosine receptors. Inhibits phosphodiesterase, which leads to intracellular accumulation of cyclic adenosine monophosphate, under the influence of which glycogenolysis processes are enhanced, metabolic processes in organs and tissues are stimulated, including muscle tissue and the central nervous system.

When administered subconjunctivally, it improves microcirculation and activates the metabolic processes of the ciliary epithelium.

Pharmacokinetics

It is quickly distributed in all organs and tissues of the body, penetrates the blood-brain barrier and the placenta. The half-life is 3.9-5.3 hours (sometimes up to 10 hours). Communication with blood proteins (albumin) - 15%. More than 90% is metabolized in the liver, in children of the first years of life up to 10-15%. Caffeine is metabolized in the liver (the main part is demethylated and oxidized) with the formation of 5 metabolites. Caffeine and its metabolites are excreted by the kidneys (10% unchanged).

Indications for use

• Decreased mental and physical performance, muscle weakness, drowsiness, migraine, moderate arterial hypotension, respiratory depression (including mild poisoning with opioid analgesics and hypnotics, carbon monoxide, asphyxia of newborns, restoration of the required level of pulmonary ventilation after the use of general anesthesia).
• Hypotony of the eyeball (after abdominal eye surgery, ciliochoroidal retinal detachment, hypotonic retinal detachment).

Contraindicated

Hypersensitivity, organic diseases of the cardiovascular system (including acute myocardial infarction, atherosclerosis), arterial hypertension, glaucoma, sleep disorders, increased excitability, old age, paroxysmal tachycardia, frequent ventricular extrasystole, epilepsy and a tendency to seizures. Pregnancy and lactation period.

Carefully: glaucoma, increased excitability, old age.

Directions for use and doses

Subcutaneously: adults 100 mg or 200 mg. The highest single dose for adults is 400 mg, the highest daily dose is 1 g. For children, 25-100 mg, depending on age. In ophthalmology, 30 mg is administered subconjunctivally once a day, daily. The number of injections depends on the intraocular pressure and the depth of the anterior chamber.

Side effect

From the nervous system: agitation, anxiety, tremor, headache, dizziness, epileptic seizures, increased tendon reflexes, tachypnea, insomnia. With sudden withdrawal - increased inhibition of the central nervous system, increased fatigue, drowsiness, increased muscle tone.

From the cardiovascular system: tachycardia, cardiac arrhythmia, increased blood pressure.

From the digestive system: nausea, vomiting, diarrhea, exacerbation of peptic ulcer.

Other: nasal congestion.

With long-term use, mild addiction is possible (a decrease in effect is associated with the formation of new adenosine receptors in brain cells), drug dependence.

Overdose

Symptoms: increased severity of side effects. In newborns (including premature infants) the following are possible: anxiety, tachypnea, tachycardia, tremor, increased Moro reflex, and at higher concentrations - convulsions.

Treatment: symptomatic therapy, oxygen therapy, hemodialysis. In newborns, if necessary, exchange blood transfusion.

Interaction with other drugs

With the combined use of caffeine and barbiturates, primidone, antiepileptic drugs (hydantoin derivatives, especially phenytoin), it is possible to increase metabolism and increase the clearance of caffeine.

Concomitant use with cimetidine, oral contraceptives, disulfiram, ciprofloxacin, norfloxacin leads to a decrease in the metabolism of caffeine in the liver, a slowdown in its elimination and an increase in concentration in the blood.

When used with caffeinated beverages and other drugs that stimulate the central nervous system, excessive stimulation of the central nervous system is possible. Caffeine is an adenosine antagonist - large doses of adenosine may be required.

Mexiletine - reduces caffeine excretion by up to 50%; nicotine - increases the rate of caffeine elimination.

Monoamine oxidase inhibitors (MAOIs), furazolidone, procarbazine and selegiline - large doses of caffeine can cause the development of dangerous cardiac arrhythmias or a marked increase in blood pressure.

Caffeine reduces the effect of narcotic and sleeping pills. Increases the excretion of lithium preparations (Li +) in the urine.

Accelerates absorption and enhances the effect of cardiac glycosides. increases their toxicity.

Concomitant use of caffeine with beta-blockers may lead to mutual suppression of therapeutic effects; with adrenergic bronchodilators - to additional stimulation of the central nervous system and other additive toxic effects.

Caffeine may decrease the clearance of theophylline and possibly other xanthines, increasing the potential for additive pharmacodynamic and toxic effects.

special instructions

It should be borne in mind that sudden cessation of use may lead to increased inhibition of the central nervous system (drowsiness, depression). The effect on the central nervous system can be manifested by both excitation and inhibition of higher nervous activity.

Release form

Solution for subcutaneous and subconjunctival administration 100 mg/ml or 200 mg/ml. 1 ml or 2 ml of 10% (100 mg/ml) or 20% (200 mg/ml) solution in neutral glass ampoules. 10 ampoules with instructions for use and a knife for opening ampoules or an ampoule scarifier in a cardboard box or 5 or 10 ampoules in a blister pack made of polyvinyl chloride film, 1 or 2 blister packs with instructions for use and a knife for opening ampoules or with an ampoule scarifier in a cardboard pack. When packaging ampoules with a break ring or break point, a knife for opening ampoules or an ampoule scarifier is not inserted.

Storage conditions

List B.

At temperatures from +15°C to +25°C Store out of the reach of children.

Best before date

6 years. Do not use after the expiration date stated on the package.

Conditions for dispensing from pharmacies:

on prescription.

The manufacturer accepts claims from buyers:

OJSC "Novosibkhimpharm", 630028, Russia, Novosibirsk, st. Dekabristov, 275